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206010052896 Ocular vascular disease Diseases 0.000 claims description 29.239000008194 pharmaceutical composition Substances 0.000 claims description 36.150000001413 amino acids Chemical class 0.000 claims description 73.

108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 101.

102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims description 101.

125000003275 alpha amino acid group Chemical group 0.000 claims description 196.229920001184 polypeptide Polymers 0.000 claims abstract description 520.230000035772 mutation Effects 0.000 claims abstract description 605.108090001123 antibodies Proteins 0.000 title claims abstract description 845.102000004965 antibodies Human genes 0.000 title claims abstract description 845.Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority to EP13165744 priority Critical Priority to EP14151316 priority Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG Priority to PCT/EP2014/058417 priority patent/WO2014177460A1/en Application granted granted Critical Publication of ES2746136T3 publication Critical patent/ES2746136T3/en Status Active legal-status Critical Current Anticipated expiration legal-status Critical Links Original Assignee F Hoffmann La Roche AG Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Inventor Guido Hartmann Joerg Thomas Regula Matthias Rueth Wolfgang Schaefer Tilman Schlothauer Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Active Application number ES14721806T Other languages Spanish ( es)

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Modified Human FcRn Binding Antibodies and Methods of Useĭownload PDF Info Publication number ES2746136T3 ES2746136T3 ES14721806T ES14721806T ES2746136T3 ES 2746136 T3 ES2746136 T3 ES 2746136T3 ES 14721806 T ES14721806 T ES 14721806T ES 14721806 T ES14721806 T ES 14721806T ES 2746136 T3 ES2746136 T3 ES 2746136T3 Authority ES Spain Prior art keywords mutations region region polypeptide antibody human Prior art date Legal status (The legal status is an assumption and is not a legal conclusion.

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